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Semax 30mg

Semax (MEHFPGP) is a synthetic heptapeptide analogue of the ACTH(4-10) fragment developed to retain specific peptide-signaling properties while exhibiting a distinct pharmacological profile.

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Semax (MEHFPGP) is a synthetic heptapeptide analogue of the ACTH(4-10) fragment developed to retain specific peptide-signaling properties while exhibiting a distinct pharmacological profile.

Experimental investigations have examined its interactions with melanocortin-associated signaling pathways, peptide-mediated regulatory networks, transcriptional control mechanisms, and signal transduction processes. Studies have also explored its influence on molecular signaling systems, receptor-associated regulatory pathways, and peptide-dependent cellular communication mechanisms.

Research applications include neuropeptide pharmacology, melanocortin pathway investigation, peptide-signaling research, transcriptional regulation studies, receptor-ligand interaction analysis, and mechanistic evaluation of peptide-mediated signaling systems.

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3D Molecular Structure

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Semax 30mg1 vial | KIT (10 vials)
Chemical Formula C37H51N9O10S
Synonyms MEHFPGP, (Pro8,Gly9,Pro10)ACTH-(4-10), H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
Molar Mass 813.93 g/mol
CAS Number 80714-61-0
PubChem CID 9811102
Total Compound Content 30 mg per vial
Shelf Life 36 months
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analogue of the ACTH(4-10) fragment. The ACTH(4-10) region lacks the steroidogenic activity associated with the N-terminal ACTH sequence while retaining interactions with melanocortin-associated signaling systems. Experimental investigations have examined Semax in relation to transcriptional regulation processes, melanocortin pathway activity, ERK/MAPK-associated signaling networks, and peptide-mediated regulatory mechanisms. Studies have also explored its influence on receptor-associated signaling systems, molecular communication pathways, and downstream regulatory processes involved in peptide pharmacology. Its heptapeptide sequence includes a C-terminal Pro-Gly-Pro motif that influences peptide stability characteristics and resistance to enzymatic degradation relative to shorter ACTH-derived fragments. These properties have established Semax as a valuable research tool for neuropeptide pharmacology, melanocortin pathway investigation, signal transduction research, receptor-ligand interaction studies, transcriptional regulation analysis, and mechanistic evaluation of peptide-mediated signaling systems. Supplied as a lyophilized preparation (30 mg/vial). Independently third-party HPLC-tested; COA available per batch.

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What is the relationship between Semax and ACTH in terms of receptor pharmacology?

Semax is derived from the ACTH(4-10) sequence, a fragment of the larger proopiomelanocortin (POMC)-derived peptide family. The ACTH(4-10) region retains interactions with melanocortin-associated signaling systems while exhibiting a pharmacological profile distinct from full-length ACTH.

Experimental investigations have examined Semax in relation to melanocortin receptor-associated pathways, peptide-mediated regulatory mechanisms, transcriptional control processes, and downstream signaling networks. These characteristics make Semax a useful research tool for studies of melanocortin pharmacology and peptide-signaling mechanisms.

How does Semax interact with molecular signaling pathways in experimental systems?

Experimental investigations have examined Semax in relation to ERK/MAPK-associated signaling networks, transcriptional regulation processes, and peptide-mediated regulatory pathways.

While the precise molecular mechanisms remain incompletely characterized, studies have explored interactions with receptor-associated signaling systems, intracellular communication pathways, and downstream regulatory networks involved in peptide pharmacology.

These characteristics have established Semax as a valuable research tool for investigations of signal transduction mechanisms and peptide-mediated molecular regulation.

Why is the Pro-Gly-Pro C-terminal motif of Semax pharmacologically significant?

Semax contains a C-terminal Pro-Gly-Pro extension that influences peptide stability characteristics and enzymatic degradation susceptibility relative to shorter ACTH-derived fragments. This structural modification alters physicochemical properties and contributes to its distinct pharmacological profile.

The Pro-Gly-Pro motif is frequently examined in studies of peptide structure-function relationships, enzymatic processing mechanisms, molecular stability, and the impact of sequence modifications on peptide-associated signaling systems.

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